Introduction
Hyaluronidase injection has emerged as a crucial solution in the field of cosmetic dermatology, especially when dealing with the aftermath of hyaluronic acid filler treatments. New York City, being a hub of medical excellence and cosmetic innovation, houses several well - reputed hospitals and clinics that offer top - notch hyaluronidase injection services. In this article, we will explore the details of hyaluronidase, its uses, and then highlight the top three well - reputed institutions for hyaluronidase injection in New York City.
Understanding Hyaluronidase
What is Hyaluronidase?
Hyaluronidase is an enzyme that occurs naturally in the body. It is produced by white blood cells to move more quickly through connective tissues. Hyaluronidase enzymes have been discovered in insects, mammalian tissues, and even snake venom. There are a variety of different hyaluronidase classifications, with the most common being Hyal1 and Hyal2. Hyaluronidase activity within Hyal2 has less enzyme activity but is able to break down hyaluronic acid with a higher molecular weight. It is an injectable enzyme that is marketed with several FDA - approved brand - name formulations, including Hydase, Hylenex, Amp Hadas e, and Vitrase.
The injections typically contain this enzyme collected from purified bovine tissue (ovine testicular hyaluronidase) or derived from human albumin sources (recombinant human hyaluronidase). For example, Hylenex, a synthetic, recombinant DNA product made from human products, has a purity 100 times higher than some of the bovine preparations, and allergic reactions to it are very rare.
What Does Hyaluronidase Do?
Hyaluronidase has a variety of FDA - approved medical functions. It is used in improving the diffusion of anesthetics in pain therapy, aiding in the absorption of treatment agents in chemotherapeutics and ophthalmic surgery, as a spreading agent in subcutaneous injections, and off - label in dissolving hyaluronic acid fillers. In the context of cosmetic dermatology, hyaluronidase works by breaking down the linkages between hyaluronic acid molecules. When injected subcutaneously, it can reverse previous cosmetic injections of hyaluronic acid fillers such as Restylane or Juvederm, ultimately decreasing the hyaluronic acid from the dermal filler and reversing its cosmetic effects.
How Does Hyaluronidase Work?
Different types of hyaluronidase work through different mechanisms of action. Hyaluronidase derived from mammals and leeches breaks down glycosidic linkages via the process of hydrolysis, which is when a chemical reaction occurs with the help of water to break a compound down. By breaking down the glycosidic linkages of hyaluronic acid, hyaluronidase leads to the decreased viscosity of hyaluronic acid molecules, contributing to the removal of the hyaluronic acid in the treatment area.
When a patient comes in for hyaluronidase treatment, they first meet with a doctor to discuss their concerns, medical history, and the amount and type of hyaluronic acid fillers they want to dissolve. Then, the doctor administers the hyaluronidase to the initial hyaluronic acid filler treatment area. The effects of hyaluronidase usually start to show within 48 hours, and most patients see complete results within two weeks. However, some patients may need a second or third treatment depending on the type and amount of the initial filler.
Is Hyaluronidase Safe?
Hyaluronidase is FDA - approved, which means it has been proven to be safe and effective for use. Similar to Juvederm and Restylane, injections of hyaluronidase are generally safe and have minimal side effects. The most common side effects include mild swelling, bruising, and tenderness at or near injection sites, which usually resolve independently within one to two weeks. A rare potential side effect is a mild allergic reaction, with a reported incidence between 0.05% and 0.69%. A skin test may be performed before the injections to evaluate for hypersensitivity.
Top Three Well - Reputed Hospitals for Hyaluronidase Injection in New York City
Dr. Michele Green's Clinic
Dr. Michele Green is an internationally renowned board - certified dermatologist with over two and a half decades of experience. She provides some of the world’s most discerning individuals with the best non - invasive cosmetic treatment options, including dermal fillers and hyaluronidase injections. Dr. Green takes a holistic approach and embraces a less - is - more philosophy regarding facial rejuvenation, customizing each patient’s treatment plan to best suit their particular skin concerns and overall aesthetic goals.
She uses Hylenex, a recombinant human hyaluronidase, for hyaluronidase treatments. This choice minimizes the risk of an allergic reaction. Her dedication to her patients and expertise has earned her consistent recognition as one of New York City’s best dermatologists by Castle Connolly, New York Magazine, and Super Doctors. If a patient has received poor results from hyaluronic acid filler injections, Dr. Green can create a customized hyaluronidase treatment plan to dissolve the unwanted filler and restore the patient's pre - filler appearance.
Dr. Debra Jaliman's Practice
Dr. Debra Jaliman is a board - certified dermatologist with over 25 years of experience in cosmetic injectables, including hyaluronic acid dermal fillers. Her NYC dermatology office often receives patients who have developed lumps or nodules on their cheeks or lips after receiving filler treatments from inexperienced practitioners at other clinics.
Dr. Jaliman has extensive experience in using hyaluronidase to correct mistakes made by other injectors. She has worked with clients of every age to solve their filler complications and problems. She offers Vitrase and Hylenex treatment to dissolve overdone or unwanted hyaluronic acid filler results. Dr. Jaliman takes a comprehensive approach to providing personalized facial rejuvenation treatments and aims to ensure patient satisfaction, delivering the best cosmetic outcomes that enhance appearance and boost confidence.
Dr. Amiya Prasad's Clinic
Dr. Amiya Prasad is a board - certified cosmetic surgeon and a fellowship - trained oculofacial plastic and reconstructive surgeon. He has been in practice in Manhattan and Long Island for over 25 years. His experience as a surgeon gives him an edge in both the injection of hyaluronic acid filler and the dissolution of hyaluronic acid with hyaluronidase, as he has a thorough understanding of facial anatomy.
Dr. Prasad often sees patients who have had improper filler placement, especially under the eyes and cheeks. He performs conservative and precise placement of hyaluronidase to dissolve the hyaluronic acid filler, and patients are generally happy with the outcome. He has had consistent success in using hyaluronidase to address the concerns of patients who are unhappy with their filler results.
Comparing the Three Institutions
| Doctor | Specialty | Experience | Hyaluronidase Product Used | Notable Achievements |
|---|---|---|---|---|
| Dr. Michele Green | Board - certified dermatologist | Over two and a half decades | Hylenex | Consistently recognized as one of NYC's best dermatologists by Castle Connolly, New York Magazine, and Super Doctors |
| Dr. Debra Jaliman | Board - certified dermatologist | Over 25 years | Vitrase, Hylenex | Expert in solving filler complications and providing personalized facial rejuvenation treatments |
| Dr. Amiya Prasad | Board - certified cosmetic surgeon, fellowship - trained oculofacial plastic and reconstructive surgeon | Over 25 years | Not specified | Success in using hyaluronidase for patients with improper filler placement, especially around the eyes, due to in - depth anatomical knowledge |
Preparing for Hyaluronidase Injection
Before receiving hyaluronidase injection, patients should take several steps to ensure a smooth and safe procedure. First, they should schedule a consultation with the chosen doctor. During this consultation, the doctor will review the patient's medical history, history of cosmetic treatments, including dermal fillers, and their specific skin care concerns and aesthetic goals. The doctor will also determine the appropriate amount of hyaluronidase needed and discuss the potential side effects and expected results.
Patients should also follow some pre - treatment protocols. They should avoid wearing makeup to the clinic on the day of the treatment to minimize the risk of infection. Additionally, they should avoid alcohol, aspirin, ibuprofen, and some dietary supplements because these substances are likely to cause bruising or swelling. It is important to give the doctor a detailed recap of their medical history to confirm that any medications they are taking are okay to use with a hyaluronidase treatment.
Aftercare for Hyaluronidase Injection
After the hyaluronidase injection, patients can usually resume normal activity as the procedure requires no downtime. However, they should follow some aftercare instructions to promote optimal healing and results. They should avoid wearing makeup at the site of injection for 12 hours and not drink excessive amounts of alcohol or engage in rigorous exercise, as these activities might cause swelling.
It is recommended to clean the area with a mild cleanser or micellar water and avoid products with fragrance and acids to prevent irritation. Sun exposure should be avoided, and sunscreen with an SPF of 30 or above should be used to protect the treated area. The doctor may also schedule a follow - up appointment to evaluate the results and determine whether any additional treatment is required.
Cost of Hyaluronidase Injection
The cost of hyaluronidase injection can vary depending on several factors. These include the amount of filler that needs to be dissolved, the type and brand of hyaluronidase used, the experience of the doctor, and the complexity of the case. On average, the treatment cost is around $1,000, but it can range from $400 - $1500 in New York City. When patients have a consultation with a doctor, they will be able to get a more accurate quote based on their specific situation.
Conclusion
Hyaluronidase injection is a valuable solution for those who are unhappy with the results of their hyaluronic acid filler treatments. In New York City, institutions led by Dr. Michele Green, Dr. Debra Jaliman, and Dr. Amiya Prasad offer top - notch hyaluronidase injection services. These doctors have extensive experience, expertise, and a patient - centered approach, making them well - reputed in the field. Whether it's dissolving improper filler placement, correcting aesthetic issues, or simply reversing the effects of overdone fillers, these institutions can provide effective and safe hyaluronidase treatments.
If you are considering hyaluronidase injection in New York City, take the time to research these doctors, schedule a consultation, and discuss your concerns and goals. With the right doctor and proper care, you can achieve the desired results and restore your confidence in your appearance. Don't hesitate to take the first step towards a more satisfying aesthetic outcome by reaching out to one of these well - reputed institutions today.
